Abstract
Introduction: Prostate cancer is one of the medical problems in male population, and is the second most common cancer. According to statistics, the prevalence of prostate cancer in Europe is 214 / 100,000 and the number of cases diagnosed each year is 2.6 million. High incidence of prostate cancer in Indonesia, made it necessary to find an examination that can be used widely in major health centers with good sensitivity and specificity. Platelet and lymphocyte counts are routinely performed in most clinical laboratories around the world, therefore we evaluate whether pretreatment PLR and NLR can predict prognosis for prostate cancer patients.
Methods: This study was conducted by using cross sectional analytical method in Urology Department of Urology Division of H. Adam Malik General Hospital Medan from 2012 until 2017. We analyzed 70 samples that met inclusion and exclusion criteria with Spearman correlation test in SPSS Statistic 23.
Results: From 70 samples that has been analyzed, we found that 42 samples (60%) subjects were diagnosed with prostate adenocarcinoma and the other 40% with prostatic hyperplasia. Median pretreatment PLR score is 175.2 (75-553.8) and median score for pretreatment NLR 3.4 (1.4-20.5). Both pretreatment PLR and NLR had a weak negative correlation with Karnofsky score (R = -0.257, p = 0.032 and R = -0.247, p = 0.039, respectively)
Conclusion: The higher number of pretreatment PLR score correlate to worse prognosis of prostate cancer patients and the higher number of pretreatment NLR score, correlate to worse prognosis of prostate cancer patients.