Abstract
Background: Activation of interstitial myofibroblasts and extracellular matrix deposits in unilateral kidney obstruction results in hydronephrosis, there will be depletion of the renal parenchyma, tubular atrophy and the formation of interstitial fibrosis. The aim of the study was to assess the profile of interstitial fibrosis and tubulus atrophy in nephrectomy patients with unilateral obsruction.
Methodology: We reviewed medical records and histopathology examinations of patients with unilateral kidney obstruction underwent nephrectomy in Arifin Achmad Regional Hospital, Pekanbaru, Riau Province of Indonesia in 2012-2017. Statistic analysis used were univariate. Approval on the study was obtained from the Ethical Review Board for Medicine and Health Research, Medical Faculty, RiauUniversity.
Results: There were 77 unilateral kidney obstruction patients underwent nephrectomies in Arifin Achmad Regional General Hospital of Riau Province in which mostly 23 (29.9%) in age 50-59 years old patients. with males were in 55.8% patients and females were in 44.3% patients. Most blood ureum level <40 mg / dl was in 81.8% patients and most blood creatinine level was <1.5 mg / dl in 79.2% patients. The most etiology was miscellaneous in 15.6%. The results of histopathologic examination were interstitial fibrosis and tubular atrophy respectively in 51.8% patients.
Conclusion: Unilateral kidney obstruction underwent nephrectomy in our hospital was characterized by mostly in elderly age, half of the patients were male, blood ureum level <40 mg/dl, blood creatinin serum <1.5 mg/dl, miscellaneous was the most cause, interstitial fibrosis and tubulus atrophy in histopathology findings.