Abstract
Guillain-Barré syndrome (GBS) represents a heterogeneous group of immune mediated peripheral neuropathies. A feature common to all GBS variants is a rapidly evolving polyradiculoneuropathy which presents as rapidly progressive ascending weakness because of a previous triggering event, most often an infection of gastrointestinal or respiratory tract. GBS rarely complicates pregnancy. If at all it occurs in pregnancy , then it is usually severe.We report a 26-year-old primigravida who developed progressive heaviness of both lower limbs in her third trimester of pregnancy followed by dyspnea , later on diagnosed to have severe form of GBS with respiratory and autonomic failure.